How Cancer Cells Overcome the Obstacle of Senescence | Sebastian Igelmann
Original Article Reference
This SciPod is a summary of the paper ‘A hydride transfer complex reprograms NAD metabolism and bypass senescence’, published in the journal Molecular Cell, https://doi.org/10.1016/j.molcel.2021.08.028
About this episode
Cellular senescence [suh-NEH-Sns] is the process by which cells age and permanently stop dividing but do not die. While the process of senescence creates a barrier to tumour formation, it can still be overcome by cancer cells. Sebastian Igelmann, a PhD student supervised by group leader Dr Gerardo Ferbeyre at the University of Montreal, has identified a group of enzymes that work together to reprogramme cellular metabolism. This work provides important insight into how tumour cells may initiate proliferation and circumvent senescence. Critically, this specialist group of enzymes provides a potential therapeutic target for human cancer treatment.
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