There is an urgent need for prognostic tools that can accurately predict the outcomes of patients undergoing treatment for breast cancer. Dr Fatima Rehman and her colleagues investigated the relationship between breast cancer prognosis and the secretion of a biological marker called Galectin-3 to drive forward the development of optimised treatment regimes. This work was conducted at Shaukat Khanum Memorial Cancer Hospital and Research Centre in Pakistan.

The potentially fatal impact of tetanus on mothers and infants is a serious issue in developing countries. Dr Syed Ahsan Raza at Baylor College of Medicine and Dr Bilal Avan at the London School of Hygiene and Tropical Medicine have recently published their perspectives and insights into this important issue.

Measurement of CD4 T cell-mediated immunity requires functional tests to be conducted with viable peripheral blood mononuclear cells, PBMC. Recently, scientists at CTL successfully developed a positive control that not only verifies the functionality of CD4 T cells in PBMC, but also that the antigen-presenting cell compartment is unimpaired in the test sample as well.

Congenital heart disease (CHD) is one of the most common birth defects across the globe. Although prospects and survival rates are improving, there is scant understanding or help available to get children with CHD active. Many believe physical activity is risky or outright dangerous, and as a result, children with CHD are at risk of obesity and other chronic conditions later in life. Dr Marta Erlandson from the University of Saskatchewan has aided the creation of CHAMPS, an innovative program for children with CHD, where researchers and children are learning how to manage the disorder from each other.

Stress is inherently prevalent in our lives and can have seriously deleterious impacts on individual health and well-being, as well as society more broadly. Dr Joseph Arpaia a psychiatrist in private practice in the USA, and colleague Dr Judith P. Andersen of the University of Toronto Mississauga in Canada, have proposed a new theoretical account of stress that has the potential to revolutionise clinical care in the fields of psychiatry and addiction, and improve well-being on a global level.

Rabies is transmitted from animals to humans through the bite of an infected animal, all too often with fatal consequences, particularly in the developing world. Dr Joanne Maki, Technical Director for the Veterinary Public Health Centre at Boehringer-Ingelheim Animal Health, has worked in rabies prevention for 30 years. With extensive background and experience gained in the rabies vaccine industry, Dr Maki shares her perspectives on the call to action to eliminate this deadly zoonotic disease.

Dr Anne Hansen is the Medical Director of the Neonatal Intensive Care Unit and Associate Chief of the Division of Newborn Medicine at Boston Children’s Hospital. With her colleagues, Dr Hansen has developed and tested a low cost, non-electrical warming mattress called the ‘Dream Warmer’ to help prevent and treat neonatal hypothermia in countries with limited medical resources. Her team has conducted extensive testing in Rwanda with results demonstrating that this medical device is safe, effective and ready for use on a wider scale.